Personal

Research Unit in Glycobiology, Cell Growth and Tissue Repair (Gly-CRRET) https://www.vjf.cnrs.fr/spip/crret/-Presentation-?lang=en

University Paris Est Créteil https://www.en.u-pec.fr/en/about-us/presentation

61, Avenue du Général de Gaulle, 94010 Créteil, France

ACCADEMIC POSITIONS (Research and Teaching) From 2009 Professor 1 st class (PR1) in Biochemistry and Glycosciences. University Paris Est Créteil, France. Research: Biochemical and cellular Mechanisms involving glycans in the regulation of tissue homeostasis.

2004-2009 Professor 2 nd class (PR2) in Biochemistry and Glycosciences. University Paris Est Créteil, France.

Research: Glycobiology of tissue homeostasis and repair. Development of Matrix Therapy based in heparan sulfate mimetics (currently in clinics: https://www.otr3.com/).

2001-2004 Assistant Professor (MCF) (Biochemistry). University Paris 12, France.

Research: Heparan mimetics in tissue repair: New concepts in regenerative medicine.

Under the mentorship of Prof. D. Barritault and Prof. J.P. Caruelle.

1997-2001 Researcher Project Manager. ValbioFrance Inc (currently OTR3), Paris, France and Central Veterinary Laboratory, Weybridge, UK.

Mission: Research of new markers for neurodegenerative diseases.

1996-1997 Post-Doct Fellow. Ecole Nationale Supérieure de Chimie, Toulouse, France.

Research: Chemical modifications of natural polysaccharides for application in biomedical research.

Team of Prof. Isabelle Borredon.

EDUCATION & SPECIAL TRAINING 2003 French National Accreditation to Direct Research (HDR). Université Paris 12, France. Topic: Glycobiology of tissue homeostasis and repair.

HDR allows a candidate accreditation to access to the body of University Professors in France. It gives recognition of the candidate’s high scientific level, the originality of its approach in a field of science, its ability to master a research strategy in a sufficiently broad scientific or technological field, and its ability to supervise research (Arrêté n° 84-52 du 23 novembre 1988 relatif à l’HDR dans l’enseignement supérieur). https://academiccareermaps.org/glossary/habilitation-a-diriger-des-recherches-hdr

1996

PhD in Pharmaceutical Sciences. Tokushima Bunri University, Tokushima, Japan.

Topic: Stereoselective syntheses of natural glycoconjugates: Arthrobacilin, trehalose dycorynomycolates (TDCMs), and their synthetic analogues.

1993-1989

Master in Pharmaceutical Sciences. Tokushima Bunri University, Tokushima, Japan.

Topic: Development of new zinc salts catalyzed glycosylation reactions.

Diploma of Pharmacist. Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Mexico. Topic: Extraction, purification, and structural characterization of natural products from traditional medicine.

SCIENTIFIC RESPONSABILITIES (Research, management, and scientific networks) From 2023 Scientific Responsible of the French Foundation of Medical Research Program REP- Regenerative Medicine 15993.

From 2020 Director of the ‘Research Unit in Glycobiology, Cell Growth and Tissue Repair’ (Gly-CRRET), University Paris Est Créteil, France.

https://www.vjf.cnrs.fr/spip/crret/-Presentation-?lang=en From 2017 Scientific leader and coordinator of the European H2020 FET OPEN RIA program 737390. Research topic: ‘3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration’.

Involving 8 teams from 5 European countries (France, IK, Poland, the Netherlands, and Spain). https://cordis.europa.eu/project/id/737390/fr From 2015 Director of the Laboratory ‘Cell Growth and Tissue Repair’ (CRRET), University Paris Est Créteil, France.

1 From 2015

Scientific Director and Founder of the ‘Glycan-Mix Platform’ at University Paris Est Créteil, France. This facility proposes to the scientific and industrial community services on the analysis of glycosaminoglycans and related polysaccharides to deep fundamental knowledge and/or to support biomedical applications. https://www.u-pec.fr/fr/recherche/plateformes/plateforme-gags-glyco-mix Member of the Scientific Comity of the Faculty of Sciences and Technology, UPEC.

2009-2014 2009-2015 2011-2012 From 2009 From 2007 2003-2006 PhD students and Post-doct fellows Director of 16 PhD students from France, China, Mexico, Netherlands, Argentina, Tunisia. Grants: MESR (France), CONACYT (Mexico), French Ministry of Foreign Relations (China), LECMA (European), CONICET (Argentina), Private sector financing (OTR3, IBSA, Boiron, Janssen, ScreenCell).

Responsible of Studies and member of the direction Border for the Post-Graduate School (Ecole doctoral) ‘Life and Health Sciences’ (SVS), University Paris Est-UPE, France.

Scientific Consultant for ‘Beijing Hospital of Traditional Chinese Medicine’, Beijing, China. Principal Investigator of the CNRS Research team ‘Glycosaminoglycans and Homeostasis’ at CRRET CNRS 9215. University Paris 12, France.

Member of Scientific Border the Company OTR3 that implemented the Matrix Therapy concept into Clinics. Paris, France.

Leader of the young researcher group ATIP/CNRS ‘Heparanome’. University Paris 12, France.

Scientific director for 13 Postdocs: France, Spain, Argentina, China. Grants: French Ministry of Foreign Relations (China), France Alzheimer, PCR7, private financing (industrial partners).

• Member of the European-Prion Network of Excellence (EuroPrion).
• Member of the French National Research Group in GAGosciences.

MAIN SCIENTIFIC CONSULTANCY (Research expertise) Since 2023: Scientific consultant for Pharma Company Glycanix.

Since 2020: Associated editor of the ‘Glycoconjugate Journal’ of the Nature-Springer Journals Group.

Since 2018: Expert for projects evaluation for European Cooperation in Scientific and Technical Research (COST) programs.

Since 2018: Expert for Scientific evaluation for the international ECO-SUD program of the French Minister of Foreign Relations & French Minister of Education and Research.

Since 2017: Expert for evaluation of International AXA Research Foundation research grants.

Since 2017: Evaluator and member of Scientific board for internal promotion of CNRS engineers.

Since 2016: Expert for evaluation of French ANRT ‘Academic-Industrial’ national PhD grants.

Since 2015: Member of the evaluation board of Ile de France PhD manuscripts awards.

Since 2014: Member of the Scientific Evaluation Committee of the University Paris Est Créteil, France.

Since 2009: Expert for evaluation of Czchex Science Foundation research grants.

Since 2009: Expert for Centre National of Scientific Research (CNRS) in ‘Interdiciplinary’ grants.

Since 2009: Expert for evaluation of French National Research Agency (ANR) for Research proposals.

Since 2006: Scientific consultant for Pharma Company OTR3.

Since 2005: Reviewer for Scientific journals: Matrix biology, Scientific reports, Oncotarget, Biomaterials, Molecules, Carbohydrate polymers, Chem Med Chem, Molecular Psychiatry, J. Alzheimer’s disease, Neurosciences, Neurosciences letters, Acta Neuropathologica, Molecular Neurosciences, translational neurodegeneration, Open Biology, Experts Reviews, Future Med Chem, Future Food International, Biomacromolecules, Advanced Material Interfaces, Naunyn-Schmiedeberg’s, Archives of Pharmacology, Jove reviews, J Am Soc Mass Spect, Thrombosis…

MAIN AWARDS AND GRANTS (Research expertise and management of research) 2022-2024 Australian ‘Foundation San Filippo’ Grant for research on the ‘Mechanisms involving heparan sulfates in cognitive decline in Saint Filippo disease’.

2021 Palm of the French Senate for Innovative Research in Alzheimer’s disease.

2018-2022 National Grant ANR SkelGAG. ‘GAGs in hereditary skeletal dysplasias with neurologic phenotypes. 2017-2022 H2020 Grant as scientific coordinator of the highest scored project FET OPEN RIA (8 groups/5 countries) ArrestAD-737390: ‘3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration’. 2015-2018 National Grant ANR MAESTRO. ‘Matrix therapy for brain : Application in stroke’.

2015-2018 Award from the European League against Alzheimer’s disease (LECMA) ‘HS sulfotransferases and synaptic stability in AD-related tauopathies’.

2013-2015 Award ‘France Alzheimer’, ‘New targets for Alzheimer’s disease’.

2013-2015 Grant SATT-IDF-Innov Grant for Scientific Innovation. ‘Glycobiology of Alzheimer’s disease: On the objective to develop -bench to bed- translational strategies’.

2011-2014 Regional Grant MEDICEN/FEDER. ‘Glycobiology-based strategies for imaging tumors’.

2010-2013 National Grant ANR Matrixcell ‘Matrix/cell therapy for tissue regeneration’ (TecSan).

2008-2011 National Grant ANR biotecS (ANR-08-BIOT) ‘New tags for imaging degenerating tissue’.

2007-2010 National Grant ANR (ANR-07-RIB) ‘Targeting extracellular matrix’.

2011 Award ‘1st prix Thèse val de Marne’ for 1 PhD (2009) and 2nd prix for 1 Master student.

2006 Award National ‘Fondation Coloplaste’ for wound healing (France).

2 2003-2007

National Grants Association Francoise against Myopathies (AFM) for ‘Glycosaminoglycans-proteins interaction in aging tissues’ (two grants 2003-2005 and 2005-2007).

2003-2006 Award CNRS ATIP for supporting youth scientists : ‘Study of the Heparanome’.

2002-2005 Participant in the European consortia NEUROPRION StopPrion (European-Union).

From 2003 PI for several industrial research contracts with small companies (OTR3, Biomup, Sephrapharma) and big pharma (Sanofi, Johnson & Johnson/Janssen).

MAIN TEACHING RESPONSABILITIES (Teaching expertise, teaching administrative and management activities) Since 2004 Full Professor of Biochemistry and Glycosciences at the University Paris Est Creteil, France. Assuring 192 h of teaching by year in front of students (L1-M2). In addition, as a professor, I must assure management of lectures, review and actualization of pedagogic contents and associated administrative responsibilities: interaction with students, organization of perfectioning committees, interaction with administrative scholar office for listings, planning (students, teachers, and classrooms, etc.). Additionally, I have the responsibility to associate ‘research component’ to the local pedagogic programs, particularly in M1 and M2, but also in L2 and L3 at some degree. This is done through the presentation of topics from local research and their collaborations with other local, national, and international research groups, and the organization of short- or long-term students’ internships.

Teaching subjects: Structural Biochemistry (L1, participation), Metabolism (L2, co-responsible, about 600 students), Enzymology (L3, responsible, about 450 students), Glycobiology for M1 (responsible, about 50 students), M2 (responsible, about 15 students), Cellular Pharmacology (M1), Proteomics and Glycomics (M2), Medicinal Chemistry (M2). I also teach in M2 Chirurgical Sciences with lectures specifically elaborated for clinicians and assure research seminars and workshops for PhD students.

Since 2005 Responsible of the Biochemistry pedagogic team at the Faculty of Sciences of the University Paris Est Creteil : currently counting 12 members including 2 professors, 5 assistants professors (lectures), and 4 technical staff, FST, UPEC, France.

2010-2011 Principal organizer of the European Intensive Program in Glycosaminoglycans and Proteoglycans, supported by ERASMUS, Euro-Glycosciences, UPEC and Industrial partners.

https://www.u-pec.fr/fr/recherche/plateformes/plateforme-gags-glyco-mix Since 2013 Founder of the Master ‘Integrative Biology Omics’ at the FST (UPEC). After having founded and directed this Master between 2013-2018, currently I am responsible of its internationalization. The master is under signature for co-diplomation with the Master in ‘Health Sciences’ of the Universidad Nacional Autonoma de Mexico (UNAM).